abstract：:Newborn rats received intraperitoneal injections of endothelin-1 in a daily dose of 5 x 10(-8)mol/kg 30 min after administration of NG-nitro-L-arginine methyl ester (9.3 x 10(-5)mol/kg intraperitoneally) from the 2nd to 6th day of life. NADPH diaphorase activity in epithelial and smooth muscle cells of the tracheobron...

journal_title：Bulletin of experimental biology and medicine

authors： Lebed'ko OA,Timoshin SS,Tsygankov VI

更新日期：2002-03-01 00:00:00

abstract：:Elimination of platelets from guinea pig splenocyte suspension (lacking megakaryocytes) with EDTA considerable reduces the efficiency cloning of splenic stromal precursor cells. It means that platelet-derived growth factors are necessary for stromal precursor cells from different organs (bone marrow, thymus, and splee...

journal_title：Bulletin of experimental biology and medicine

authors： Gorskaya YF,Shuklina EY,Nesterenko VG

更新日期：2002-03-01 00:00:00

abstract：:Peculiarities of skin extension under vacuum applicators (nozzles) of various design was studied in 20 volunteers aged 18-25 years. The data obtained made it possible to chose optimal parameters of elastic membranes of the vacuum cups that produce stretch sufficient for vacuum-membrane skeletal muscle extension with m...

journal_title：Bulletin of experimental biology and medicine

authors： Alekseev YN,Smirnov BM,Alekseev NY

更新日期：2002-02-01 00:00:00

abstract：:Behavioral responses of 90-day-old male offspring from female Wistar rats exposed to restraint stress during the last week of pregnancy were studied in the formalin test. Specific biphasic behavioral response characterized acute (phase 1) and persistent tonic pain (phase 2). The intensity of nociceptive responses (eva...

journal_title：Bulletin of experimental biology and medicine

authors： Butkevich IP

更新日期：2002-02-01 00:00:00

abstract：:Changes in the amplitude and dynamic parameters of purposive saccades were studied in monkeys with MPTP-induced Parkinson-like syndrome. Lengthening of saccade latency, decreased maximum velocity of eye movements, and impaired saccade accuracy were observed at the early stages MPTP-syndrome. Different disturbances of ...

journal_title：Bulletin of experimental biology and medicine

authors： Tereshchenko LV,Yudin AG,Kuznetsov Y,Latanov AV,Shul'govskii VV

更新日期：2002-02-01 00:00:00

abstract：:Intraperitoneal administration of substance S-1 to male Wistar rats with impaired hearing markedly increased hearing acuity. Substance S-1 had no negative effects on hearing in intact animals. ...

journal_title：Bulletin of experimental biology and medicine

authors： Shestakova EV

更新日期：2002-01-01 00:00:00

abstract：:Interleukin-1beta mRNA, interleukin-1beta receptor mRNA, and erythropoietin receptor mRNA are expressed in the brain of (CBAxC57Bl)F1 mice. Immunization with sheep erythrocytes stimulated the expression of these cytokines in the cerebral hemispheres. Injection of recombinant erythropoietin reduced expression of interl...

journal_title：Bulletin of experimental biology and medicine

authors： Poveshchenko AF,Markova EV,Korotkova NA,Yakushenko EV,Abramov VV,Kozlov VA

更新日期：2002-01-01 00:00:00

abstract：:We studied brown adipose tissue isolated from mice receiving 20% ethanol as a single source of fluid. In vitro O2 utilization by brown adipose tissue decreased after one month of forced alcohol intake, but surpassed the control after 3 months of ethanol drinking. The absolute and relative weight of brown adipose tissu...

journal_title：Bulletin of experimental biology and medicine

authors： Elsukova EI,Medvedev LN,Kudryavtseva NA

更新日期：2001-12-01 00:00:00

abstract：:Effect of one-day and chronic (3 week) drinking of 0.1% caffeine as a single source of fluid on anxiety in rats with different anxiety level (either genetically determined or individually acquired) was studied. When housed in groups, Fisher-344 rats had a significantly higher anxiety level than WAG/G rats. When the ra...

journal_title：Bulletin of experimental biology and medicine

authors： Sudakov SK,Medvedeva OF,Rusakova IV,Figurina IB

更新日期：2001-12-01 00:00:00

abstract：:We studied erythropoiesis in newborn infants delivered by mothers with normal pregnancy and gestosis. The effects of placental extracts on hemopoiesis in JCR mice were also evaluated. Our results suggest that the placenta is involved in the regulation of fetal erythropoiesis. The placenta activates fetal erythropoiesi...

journal_title：Bulletin of experimental biology and medicine

authors： Evseenko DA,Tsirel'nikov NI

更新日期：2001-11-01 00:00:00

abstract：:The significance of neurospecific proteins in the diagnosis of neurotoxicity in patients with breast, lung, testicular, and ovarian cancer treated by taxane and cisplatin drugs was evaluated. The most pronounced increase in the content of these proteins and titers of autoantibodies to these proteins was observed in pa...

journal_title：Bulletin of experimental biology and medicine

authors： Lyubimova NV,Toms MG,Shakirova IN,Gurina OI,Kushlinskii NE

更新日期：2001-11-01 00:00:00

abstract：:A series of short neurotoxins (molecular weight 3500-5000 D) was isolated from Vietnamese scorpion B. occitanus sp. All these toxins blocked generation of action potentials (this effect depended on their molecular weight), but did not change conduction velocity and excitation threshold of the nerve. ...

journal_title：Bulletin of experimental biology and medicine

authors： Hoang NA,Maksimov GV,Berezin BB,Piskarev VE,Yamskov IA

更新日期：2001-10-01 00:00:00

abstract：:Immunosorbent removing beta2-microglobulin from human blood plasma was synthesized on the basis of sheep monospecific polyclonal antibodies to beta2-microglobulin and conditions ensuring effective regeneration of the immunosorbent for its repeated use were selected. Relationships between adsorption capacity and the vo...

journal_title：Bulletin of experimental biology and medicine

authors： Shabunina IV,Afanas'eva OI,Pokrovskii SN

更新日期：2001-10-01 00:00:00

abstract：:We studied morphological changes in the myocardium during experimental myocardial infarction in rats with different resistance to hypoxia. Microscopic examination showed that morphological changes in the ischemic zone and adjacent tissues are different in rats with high and low resistance to acute ischemia. In highly ...

journal_title：Bulletin of experimental biology and medicine

authors： Karimov KY,Saidov AB,Israilov RI

更新日期：2001-10-01 00:00:00

abstract：:Ultrastructure of myocardial microvessels was examined during surgical correction of congenital heart disease (ventricular septal defect) under conditions of cold and pharmacological low-potassium cardioplegia without perfusion. Addition of calcium antagonist verapamil to cardioplegic solution prevented postischemic d...

journal_title：Bulletin of experimental biology and medicine

authors： Volkov AM,Kazanskaya GM,Chasovskikh GG,D'yakonitsa TM,Zhdanov GP,Lomivorotov VN

更新日期：2001-09-01 00:00:00

abstract：:Loading of neutrophils with immune complexes changed their functional activity and intracellular pH. These changes depended on the size of immune complexes. UV irradiation of neutrophils loaded with immune complexes led to a molecular weight-dependent decrease in intracellular pH. After irradiation the chemiluminescen...

journal_title：Bulletin of experimental biology and medicine

authors： Konstantinova NA,Khomyakova NF

更新日期：2001-09-01 00:00:00

abstract：:Morphological and histoenzymatic changes in cells of the spinal cord and spinal ganglia after epidural injection of a combination of prosidol with clonidine were studied on dogs. No pathological structural and metabolic changes in the nervous tissue were found after combined treatment with the test drugs. Higher activ...

journal_title：Bulletin of experimental biology and medicine

authors： Volchkov VA,Strashnov VI,Tomson VV,Boikova NV,Zaitsev AA

更新日期：2001-09-01 00:00:00

abstract：:Histaminergic contractile reactions of smooth muscles in rabbit lobar pulmonary arteries were studied using in vitro mechanographic technique. Histamine via activation of H-receptors induced a dose-dependent constriction of smooth muscle segments, while endothelium inhibited histamine-induced contractile reactions. Hi...

journal_title：Bulletin of experimental biology and medicine

authors： Kapilevich LV,Anfinogenova YD,Nosarev AV,Baskakov MB,Kovalev IV,D'yakova EY,Medvedev MA

更新日期：2001-08-01 00:00:00

abstract：:We studied the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia before and after treatment with simvastatin. Individual phospholipids were separated by thin-layer chromatography on glass plates coated with silica gel. It was found that apart from hypolipidemic effect, simvast...

journal_title：Bulletin of experimental biology and medicine

authors： Ozerova IN,Paramonova IV,Olfer'ev AM,Akhmedzhanov NM,Aleksandrova MA,Perova NV

更新日期：2001-08-01 00:00:00

abstract：:Biopsy specimens from patients with psoriasis treated with antiproliferative drugs (methotrexate, etretinate) were analyzed. Acanthosis and papillomatosis of the epidermis and inflammatory reaction of the derma decreased. A tendency to normalization of epidermocyte ultrastructure with regeneration of tonofilaments and...

journal_title：Bulletin of experimental biology and medicine

authors： Krinitsyna YM,Nepomnyashchikh GI,Aidagulova SV

更新日期：2001-08-01 00:00:00

abstract：:We studied in vitro cytostatic effect of doxorubicin on bone marrow cells preincubated with NAD and reduced glutathione. The presence of NAD and glutathione in the medium potentiated membrane toxicity of this antibiotic, but prevented its toxic effects on intracellular pool of pyridine nucleotides during oxidative str...

journal_title：Bulletin of experimental biology and medicine

authors： Egorova AB,Uspenskaya YA,Nefedov VP

更新日期：2001-07-01 00:00:00

abstract：:The content of urokinase- and tissue-type plasminogen activators and plasminogen activator inhibitor PAI-1 in the cytosol of primary and metastatic melanomas and benign skin pigment neoplasms was estimated by enzyme immunoassay. It was shown that local growth and invasion of melanomas are related to suppressed express...

journal_title：Bulletin of experimental biology and medicine

authors： Gershtein ES,Medvedeva SV,Babkina IV,Kushlinskii NE,Trapeznikov NN

更新日期：2001-07-01 00:00:00

abstract：:Fluorescent granular cells of the thymus lobule containing neurotransmitter monoamines express Ia antigen and S-100 protein, which attests to their macrophage origin; positive staining with aldehyde fuchsin points to secretion of peptide hormones by these cells. These facts and the absence of phagocytic activity allow...

journal_title：Bulletin of experimental biology and medicine

authors： Gordon DS,Sergeeva VE,Smorodchenko AT,Kirillov NA,Petrova TL,Olangin OI,Spirin IV

更新日期：2001-07-01 00:00:00

abstract：:Activation of free radical oxidation and inhibition of antioxidant activity in mouse myocardium after long-term dipyridamole treatment were demonstrated using chemiluminescent techniques. At the same time, dipyridamole 10-fold inhibited free radical oxidation and slightly increased antioxidant activity in the plasma. ...

journal_title：Bulletin of experimental biology and medicine

authors： Ivasenko IN,Shlyakhto EV

更新日期：2001-06-01 00:00:00

abstract：:In patients with ovarian cancer, the colony-forming capacity and radiosensitivity of clonogenic tumor cells from the primary node and metastases (ascites) differed considerably. ...

journal_title：Bulletin of experimental biology and medicine

authors： Kolesnikova AI,Sychenkova NI,Konoplyannikov AG,Lepekhina LA,Kal'sina SS,Krikunova LI,Mardynskii YS

更新日期：2001-06-01 00:00:00

abstract：:Hypochlorite produced in vivo by activated neutrophils, monocytes, and macrophages modifies blood lipoproteins and intensifies free radical lipid peroxidation, which probably plays a key role in the early stages of atherosclerotic vascular damages. ...

journal_title：Bulletin of experimental biology and medicine

authors： Panasenko OM,Sergienko VI

更新日期：2001-05-01 00:00:00

abstract：:Free radical oxidation of arachidonic acid with soybean lipoxygenase was accompanied by inhibition of retinal synthesis from beta-carotene catalyzed by enzyme preparation from rabbit intestinal mucosa. Lipoxygenase inhibitor salicylhydroxamic acid and antioxidants suppressing free radical reactions (ethyl gallate, alp...

journal_title：Bulletin of experimental biology and medicine

authors： Gessler NN,Gomboeva SB,Shumaev KB,Bykhovskii VY,Lankin VZ

更新日期：2001-05-01 00:00:00

abstract：:We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of ...

journal_title：Bulletin of experimental biology and medicine

authors： Rozenfel'd SV,Togo EF,Mikheev VS,Popovich IG,Zabezhinskii MA,Anisimov VN

更新日期：2001-05-01 00:00:00

abstract：:Dysregulation of neuroimmune connections is a primary or secondary pathogenic factor of some CNS diseases. Autoimmune aggression is typical of multiple sclerosis, Alzheimer's disease, and epilepsy, while dysregulation characterized by enhanced production of autoantibodies to neurotransmitters and activation of cell fa...

journal_title：Bulletin of experimental biology and medicine

authors： Evseev VA,Davydova TV,Mikovskaya OI

更新日期：2001-04-01 00:00:00

abstract：:Local injection of 4 nmol moxonidine (unilaterally) into the rostroventrolateral medulla of spontaneously hypertensive rats (SHR-SP) decreased mean blood pressure and heart rate by 24+/-3 and 3+/-4%, respectively. Pretreatment with the I1/alpha2-receptor antagonist efaroxan abolished the moxonidine-induced decrease in...

journal_title：Bulletin of experimental biology and medicine

authors： Khokhlova ON,Murashev AN,Medvedev OS

更新日期：2001-04-01 00:00:00

abstract：:In vivo cytogenetic effects of cyclophosphamide was simultaneously evaluated in 7 mouse organs. Cyclophosphamide produced most pronounced changes in the urinary bladder and bone marrow, the main target organs for this carcinogen. Mutagenic effects of the preparation were also detected in the lungs, large intestine, an...

journal_title：Bulletin of experimental biology and medicine

authors： Sycheva LP

更新日期：2001-04-01 00:00:00

abstract：:Systemic administration of ACTH to rats with normal hormone production induced a rapid (started 3 min postinjection) and long-term (persisted 30 min) elevation of pain threshold. Complete inhibition of glucocorticoid production shortened the duration of ACTH-induced analgesia to 15 min. The biphasic effect of ACTH on ...

journal_title：Bulletin of experimental biology and medicine

authors： Bogdanov AI,Yarushkina NI

更新日期：2001-03-01 00:00:00

abstract：:We studied competitive activities of 16 alpha,17 alpha-cyclohexano-5 alpha- and 5 beta-dihydroprogesterone in replacing(3)H-progesterone and(3)H-16 alpha,17 alpha-cyclohexano-6 alpha-methylprogesterone from protein complexes. Direct binding of(3)H-5-reduced derivatives with proteins of soluble fractions from rat and r...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnov AN,Pokrovskaya EV,Levina IS,Kulikova LE,Kamernitskii AV,Shevchenko VP

更新日期：2001-03-01 00:00:00

abstract：:Presentation of visual and acoustic stimuli at a rate of 2-30 Hz modulated variability of the heart rhythm in volunteers. Potentation of vagal influences and a decrease in the contribution of ergotropic systems to the regulation of the heart rate were noted after 10 sessions of audiovisual stimulation. These changes w...

journal_title：Bulletin of experimental biology and medicine

authors： Zagulova DV,Podkopaeva TI,Vasil'ev VN,Medvedev MA

更新日期：2001-03-01 00:00:00

abstract：:The rates of oxyhemoglobin drop and CO(2) release in dogs with magnetized and nonmagnetized blood were compared. Stationary magnetic field enhances blood oxygen capacity by no less than 24%. A hypothesis was proposed on formation of bioxyhemoglobin molecules under the effect of magnetic field, in which hem binds two O...

journal_title：Bulletin of experimental biology and medicine

authors： Zhernovoi AI,Skorik VI,Chirukhin VA,Sharshina LM

更新日期：2001-02-01 00:00:00

abstract：:Fifty-three transplantations of pituitary tissue (intact and minced with scissors) under the tunica albuginea testis were carried out. In both series pituitary cells retained viability for up to 6 months. Transplantation of cell suspension was not accompanied by the formation of necrotic zone in the transplant; the ad...

journal_title：Bulletin of experimental biology and medicine

authors： Dendeberov ES

更新日期：2001-02-01 00:00:00

abstract：:Phosphatidylcholine liposomes in a dose of 25 mg/kg displayed wound-healing properties. They increased the count of alveolar macrophages, lymphocytes, and microvessels in damaged regions and, therefore, attenuated emphysematous changes in the lungs. ...

journal_title：Bulletin of experimental biology and medicine

authors： Kornilova ZK,Selishcheva AA,Perel'man MI

更新日期：2001-02-01 00:00:00

abstract：:We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in...

journal_title：Bulletin of experimental biology and medicine

authors： Litvinova SV,Aristova VV,Shul'govskii VV,Basharova LA,Terebilina NN,Panchenko LF

更新日期：2001-01-01 00:00:00

abstract：:Electron microscopy of the pineal gland in gamma-irradiated rats treated with epithalon revealed ultrastructural signs attesting to enhancement of its functional activity. ...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VK,Yakovleva ND,Popuchiev VV,Kvetnoi IM,Manokhina RP

更新日期：2001-01-01 00:00:00

abstract：:Transplantation of erythroid and bone marrow cells to irradiated mice stimulated exogenous colony formation. Pretreatment of erythroid cells with specific rabbit antiserum to erythroblasts abolished this effect. The reverse transcriptase polymerase chain reaction revealed the presence of mRNA for interleukin-1alpha, i...

journal_title：Bulletin of experimental biology and medicine

authors： Sennikov SV,Inzhelevskaya TV,Eremina LV,Kozlov VA

更新日期：2000-12-01 00:00:00